. <i ie / sae | 2 7 a vi j J} dy . CAUTIONS— Signs of masculinization which have been ora by testosterone therapy in women have ranged from mild acne, hoarsening of the voice and an increase or darkening of the hair of the face. Women and children under seven years of age are more sensitive to androgen therapy. Durabolin, which is far less androgenic than testosterone, has not produced these signs when given in the recommended doses, save for a few of the milder of these effects which have disappeared when treatment has been discontinued. As is common with other steroids of this class, it may be possible with large doses or intensive treatment during the first half of the menstrual cycle to inhibit menses; however, with recommended doses, menses are not apt to be disturbed. Liver Function With Durabolin therapy, no instances of jaundice and no deterioration of liver function have been reported in clinical evaluations of this drug. This compound does not have a methyl or ethyl group in the 17-position, as do oral anabolic steroids which have been associated with jaundice. When disturbances of liver function are known to be present and Durabolin is also indicated, the course of liver function should be watched and Durabolin therapy discontinued if favorable effect is not evident. Edema—In retention recommended of sodium doses or water. Durabolin does not usually cause However, it should be borne in mind that malnourished or anemic patients have a tendency to develop edema and this is exaggerated in the presence of cardiac or renal failure. In mild conditions of this kind, the tendency to edema may be expected to improve with reduction of the salt intake and coincidental improvement in nutrition and blood count. This will be reflected by a return toward normal of the plasma protein, hematocrit and hemoglobin values. In mild cases of cardiac and renal tailure, especially when Durabolin is first started, increased physical exertion due to a feeling of well-being might increase the edema. This should be only temporary, especially if the salt intake is reduced and the cardiac and renal status otherwise cared for. In serious cardiac failure, one would not employ Durabolin therapy. Inoperable with or mammary without cancer—Women treatment with with skeletal metastases anabolic steroids may develop ry bovcsicemniach nd @xelare ed hyperickeluriay sbheiomay lead We UHOUN ToNiGP ng nceeOl a SONI CR Attention has been called to this type of hypercalcemia after testosterone treatment. Thus far, hypercalcemia has never been noted after Durabolin treatment, but by way of special precaution, determination of calcium values this treatment. of serum and urine _CONTRAINDICATIONS— Durabolin are recommended is contraindicated to evaluate in | prostatic cancer, or serious cardiorenal failure. | PACKAGE INFORMATION— Dubalsole (nandrolone’ phenpropionate in sterile sesame oil solution for intramuscular injection) is available in 5 cc. multiple dose vials and in 1 cc. ampuls, each cc. containing 25 mg. of nandrolone phenpropionate. ORGANON INC. + WEST ORANGE, NEW JERSEY Du-1U Ptd.ia U.S.A.